One of South Park co-creator Trey Parker’s first productions was a sketch for his 6th grade school variety show called “The Dentist.” There was so much fake blood involved that the sketch upset kindergarten students in the audience and Parker’s parents were called.
After Kanye’s interruption of Taylor Swift’s acceptance speech, Comedy Central played a South Park episode mocking Kanye’s ego, four times in a row, back to back.
Netflix, iTunes, Hulu and Amazon have all refused to stream the 200th and 201st episode of South Park due to the appearance of Muhammad in them. They are currently unavailable to watch anywhere legally as South Park was also forced to partially censor the episodes on the DVD releases.
Trey Parker almost made an action movie about a mentally disabled 9-year-old boy defending his small Colorado town from being destroyed by eight-foot-tall monsters that live in the mountains, but had to ultimately quit the project to pursue South Park.
A gene that causes an adult fruit fly to die within 2 days was named in honor of Kenny from South Park.