The fish Sarpa salpa (known as the dreamfish) is hallucinogenic. In 2006, two men who ate the fish described experiencing frightening hallucinations that lasted for 36 hours. These hallucinogenic fishes suggested to contain DMT where one experience is described as “After eating, he experienced intense hallucinations with a science-fiction theme that included futuristic vehicles, images of space exploration, and monuments marking humanity’s first trips into space”.
True History is considered the earliest form of science fiction written in 2nd century about adventurers who travel to outer space and get involved in interplanetary warfare between the king of the Moon and the king of the Sun.
The first science-fiction work was written in the 2nd Century AD by a Greek named Lucian. It has aliens, inter-planetary warfare, and cloud-centaurs.